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Microscope, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 97/100, based on 1814 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fluorescence+microscope/Leica+DM500+Microscopes/pm42913898-121-11-13
Average 97 stars, based on 1814 article reviews
Microscope, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 97/100, based on 1814 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fluorescence+microscope/Leica+DM500+Microscopes/pm42913898-121-11-13
Average 97 stars, based on 1814 article reviews
microscope - by Bioz Stars,
2026-11
97/100 stars
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Incubation:Article Title: Invasion of Clavibacter michiganensis into the Xylem and Surrounding Tissues Drives Histological Alterations and Disease Development in Tomato Article Snippet: The sections were gently rinsed with sterilized distilled water, placed on glass slides, and observed using a Article Title: CXM102 Regulates the Multiple Differentiation and Anti-Inflammation of Human Bone Marrow-Derived Leptin Receptor-Positive Stromal Cells In Vitro . Article Snippet: Bone marrow-derived leptin receptor-expressing (LepR) stromal cells (LepR BMSCs) have been identified as the primary source of osteoblasts, adipocytes, and fibroblasts in the bone marrow, and they play key roles in the maintenance of the bone marrow microenvironment; however, research on the fate and immunomodulatory changes of human LepR BMSCs is limited.. Here, we isolated LepR BMSCs from a young donor and studied their fate changes of osteogenic, adipogenic, myogenic differentiation, and immunomodulation with or without CXM102, a novel compound that we have previously demonstrated its anti-osteoporotic effects in mice.. Our results showed that CXM102 facilitated a preferential lineage shift toward osteogenesis from adipogenesis of LepR BMSCs in vitro, as evidenced by increased RUNX 2 expression and decreased PPARc in a bivalent differentiation system. Article Title: Microenvironment-informed carrier-free maltol-arginine nanoparticles harness CAT2-associated arginine transport for spermatogenic disorders. Article Snippet: Spermatogenic disorders are a major cause of male infertility, with oxidative stress-driven Leydig cell dysfunction serving as a key pathological contributor.. However, effective antioxidant therapy remains limited by insufficient accumulation in injured testes and by the formulation complexity associated with conventional carrier-based delivery systems.. Here, we investigated the pathological microenvironment of di(2-ethylhexyl) phthalate (DEHP)-injured testes and found increased inducible nitric oxide synthase (iNOS) expression together with upregulation of the cationic amino acid transporter 2 (CAT2) in the testicular interstitium, indicating altered arginine metabolism and transport. Article Title: Synergistic construction of low-temperature-resistant, water-retaining, and cushioning hydrogels via 1-s UV curing and ethylene glycol annealing for postharvest fruit protection. Article Snippet: Hydrogels are promising cushioning materials for fresh produce packaging because of their viscoelasticity, deformability, and energy-dissipation capability.. In this study, a UV-curable hydrogel based on methacrylated hyaluronic acid (HAMA) was developed.. Through ethylene glycol (EG) annealing, a cushioning material (HAMAEG) with good low-temperature tolerance and high water retention was fabricated. Article Title: Targeting the Calcium-mtDNA-cGAS-STING Signaling Nexus: A Novel Redox Mechanism for Nimodipine's Neuroprotection in Traumatic Brain Injury. Article Snippet: After incubation at 37 C for 1 h, cells were observed under a Article Title: zDHHC11 is a common palmitoyltransferase regulating microglia-mediated neuroinflammation across neurodegenerative diseases. Article Snippet: Purpose: Microglia-mediated neuroinflammation is a shared feature across Alzheimer's disease (AD), Parkinson's disease (PD), and diabetic cognitive impairment (DCI), but the convergent molecular mechanisms remain unclear.. This study investigated whether protein S-palmitoylation serves as a common regulator of microglial neuroinflammation across distinct neurodegenerative diseases etiologies and aimed to identify the key palmitoyltransferase involved.. Methods: In vivo ND models (APP/PS1 for AD, MPTP for PD, STZ/high-fat diet for DCI) and in vitro BV2 microglial models stimulated with amyloid-β (Aβ), lipopolysaccharide (LPS), or high glucose (HG) were established. Article Title: The PIEZO1/CISD1/IP3R Mechanotransduction Axis Drives Macrophage Mitochondrial Dysfunction and Inflammatory Activation in Pulmonary Fibrosis Article Snippet: Images were obtained under a Article Title: Methylglyoxal exposure at dietary-relevant concentrations induces cognitive deficits through dopaminergic damage system and metabolic perturbation in zebrafish larvae. Article Snippet: This study investigated the effects of MGO exposure at dietary-relevant concentrations on cognitive function and the underlying mechanisms using zebrafish larvae.. Behavioral assessments demonstrated that MGO induced dose-dependent cognitive impairment, with the medium and high dose groups showing a remarkable reduction in spatial memory and locomotor activity.. Mechanistic investigations revealed that MGO triggered substantial oxidative stress, evidenced by suppressed antioxidant enzyme activities (SOD and CAT decreased by approximately 30% and 28%, respectively, in the high-dose group) and elevated lipid peroxidation (MDA increased by 3.5-fold). Fluorescence:Article Title: Invasion of Clavibacter michiganensis into the Xylem and Surrounding Tissues Drives Histological Alterations and Disease Development in Tomato Article Snippet: The sections were gently rinsed with sterilized distilled water, placed on glass slides, and observed using a Article Title: CXM102 Regulates the Multiple Differentiation and Anti-Inflammation of Human Bone Marrow-Derived Leptin Receptor-Positive Stromal Cells In Vitro . Article Snippet: Bone marrow-derived leptin receptor-expressing (LepR) stromal cells (LepR BMSCs) have been identified as the primary source of osteoblasts, adipocytes, and fibroblasts in the bone marrow, and they play key roles in the maintenance of the bone marrow microenvironment; however, research on the fate and immunomodulatory changes of human LepR BMSCs is limited.. Here, we isolated LepR BMSCs from a young donor and studied their fate changes of osteogenic, adipogenic, myogenic differentiation, and immunomodulation with or without CXM102, a novel compound that we have previously demonstrated its anti-osteoporotic effects in mice.. Our results showed that CXM102 facilitated a preferential lineage shift toward osteogenesis from adipogenesis of LepR BMSCs in vitro, as evidenced by increased RUNX 2 expression and decreased PPARc in a bivalent differentiation system. Article Title: Microenvironment-informed carrier-free maltol-arginine nanoparticles harness CAT2-associated arginine transport for spermatogenic disorders. Article Snippet: Spermatogenic disorders are a major cause of male infertility, with oxidative stress-driven Leydig cell dysfunction serving as a key pathological contributor.. However, effective antioxidant therapy remains limited by insufficient accumulation in injured testes and by the formulation complexity associated with conventional carrier-based delivery systems.. Here, we investigated the pathological microenvironment of di(2-ethylhexyl) phthalate (DEHP)-injured testes and found increased inducible nitric oxide synthase (iNOS) expression together with upregulation of the cationic amino acid transporter 2 (CAT2) in the testicular interstitium, indicating altered arginine metabolism and transport. Article Title: Synergistic construction of low-temperature-resistant, water-retaining, and cushioning hydrogels via 1-s UV curing and ethylene glycol annealing for postharvest fruit protection. Article Snippet: Hydrogels are promising cushioning materials for fresh produce packaging because of their viscoelasticity, deformability, and energy-dissipation capability.. In this study, a UV-curable hydrogel based on methacrylated hyaluronic acid (HAMA) was developed.. Through ethylene glycol (EG) annealing, a cushioning material (HAMAEG) with good low-temperature tolerance and high water retention was fabricated. Article Title: Targeting the Calcium-mtDNA-cGAS-STING Signaling Nexus: A Novel Redox Mechanism for Nimodipine's Neuroprotection in Traumatic Brain Injury. Article Snippet: After incubation at 37 C for 1 h, cells were observed under a Article Title: zDHHC11 is a common palmitoyltransferase regulating microglia-mediated neuroinflammation across neurodegenerative diseases. Article Snippet: Purpose: Microglia-mediated neuroinflammation is a shared feature across Alzheimer's disease (AD), Parkinson's disease (PD), and diabetic cognitive impairment (DCI), but the convergent molecular mechanisms remain unclear.. This study investigated whether protein S-palmitoylation serves as a common regulator of microglial neuroinflammation across distinct neurodegenerative diseases etiologies and aimed to identify the key palmitoyltransferase involved.. Methods: In vivo ND models (APP/PS1 for AD, MPTP for PD, STZ/high-fat diet for DCI) and in vitro BV2 microglial models stimulated with amyloid-β (Aβ), lipopolysaccharide (LPS), or high glucose (HG) were established. Article Title: The PIEZO1/CISD1/IP3R Mechanotransduction Axis Drives Macrophage Mitochondrial Dysfunction and Inflammatory Activation in Pulmonary Fibrosis Article Snippet: Images were obtained under a Article Title: Methylglyoxal exposure at dietary-relevant concentrations induces cognitive deficits through dopaminergic damage system and metabolic perturbation in zebrafish larvae. Article Snippet: This study investigated the effects of MGO exposure at dietary-relevant concentrations on cognitive function and the underlying mechanisms using zebrafish larvae.. Behavioral assessments demonstrated that MGO induced dose-dependent cognitive impairment, with the medium and high dose groups showing a remarkable reduction in spatial memory and locomotor activity.. Mechanistic investigations revealed that MGO triggered substantial oxidative stress, evidenced by suppressed antioxidant enzyme activities (SOD and CAT decreased by approximately 30% and 28%, respectively, in the high-dose group) and elevated lipid peroxidation (MDA increased by 3.5-fold). Microscopy:Article Title: Invasion of Clavibacter michiganensis into the Xylem and Surrounding Tissues Drives Histological Alterations and Disease Development in Tomato Article Snippet: The sections were gently rinsed with sterilized distilled water, placed on glass slides, and observed using a Article Title: CXM102 Regulates the Multiple Differentiation and Anti-Inflammation of Human Bone Marrow-Derived Leptin Receptor-Positive Stromal Cells In Vitro . Article Snippet: Bone marrow-derived leptin receptor-expressing (LepR) stromal cells (LepR BMSCs) have been identified as the primary source of osteoblasts, adipocytes, and fibroblasts in the bone marrow, and they play key roles in the maintenance of the bone marrow microenvironment; however, research on the fate and immunomodulatory changes of human LepR BMSCs is limited.. Here, we isolated LepR BMSCs from a young donor and studied their fate changes of osteogenic, adipogenic, myogenic differentiation, and immunomodulation with or without CXM102, a novel compound that we have previously demonstrated its anti-osteoporotic effects in mice.. Our results showed that CXM102 facilitated a preferential lineage shift toward osteogenesis from adipogenesis of LepR BMSCs in vitro, as evidenced by increased RUNX 2 expression and decreased PPARc in a bivalent differentiation system. Article Title: Microenvironment-informed carrier-free maltol-arginine nanoparticles harness CAT2-associated arginine transport for spermatogenic disorders. Article Snippet: Spermatogenic disorders are a major cause of male infertility, with oxidative stress-driven Leydig cell dysfunction serving as a key pathological contributor.. However, effective antioxidant therapy remains limited by insufficient accumulation in injured testes and by the formulation complexity associated with conventional carrier-based delivery systems.. Here, we investigated the pathological microenvironment of di(2-ethylhexyl) phthalate (DEHP)-injured testes and found increased inducible nitric oxide synthase (iNOS) expression together with upregulation of the cationic amino acid transporter 2 (CAT2) in the testicular interstitium, indicating altered arginine metabolism and transport. Article Title: Synergistic construction of low-temperature-resistant, water-retaining, and cushioning hydrogels via 1-s UV curing and ethylene glycol annealing for postharvest fruit protection. Article Snippet: Hydrogels are promising cushioning materials for fresh produce packaging because of their viscoelasticity, deformability, and energy-dissipation capability.. In this study, a UV-curable hydrogel based on methacrylated hyaluronic acid (HAMA) was developed.. Through ethylene glycol (EG) annealing, a cushioning material (HAMAEG) with good low-temperature tolerance and high water retention was fabricated. Article Title: Targeting the Calcium-mtDNA-cGAS-STING Signaling Nexus: A Novel Redox Mechanism for Nimodipine's Neuroprotection in Traumatic Brain Injury. Article Snippet: After incubation at 37 C for 1 h, cells were observed under a Article Title: zDHHC11 is a common palmitoyltransferase regulating microglia-mediated neuroinflammation across neurodegenerative diseases. Article Snippet: Purpose: Microglia-mediated neuroinflammation is a shared feature across Alzheimer's disease (AD), Parkinson's disease (PD), and diabetic cognitive impairment (DCI), but the convergent molecular mechanisms remain unclear.. This study investigated whether protein S-palmitoylation serves as a common regulator of microglial neuroinflammation across distinct neurodegenerative diseases etiologies and aimed to identify the key palmitoyltransferase involved.. Methods: In vivo ND models (APP/PS1 for AD, MPTP for PD, STZ/high-fat diet for DCI) and in vitro BV2 microglial models stimulated with amyloid-β (Aβ), lipopolysaccharide (LPS), or high glucose (HG) were established. Article Title: The PIEZO1/CISD1/IP3R Mechanotransduction Axis Drives Macrophage Mitochondrial Dysfunction and Inflammatory Activation in Pulmonary Fibrosis Article Snippet: Images were obtained under a Article Title: Methylglyoxal exposure at dietary-relevant concentrations induces cognitive deficits through dopaminergic damage system and metabolic perturbation in zebrafish larvae. Article Snippet: This study investigated the effects of MGO exposure at dietary-relevant concentrations on cognitive function and the underlying mechanisms using zebrafish larvae.. Behavioral assessments demonstrated that MGO induced dose-dependent cognitive impairment, with the medium and high dose groups showing a remarkable reduction in spatial memory and locomotor activity.. Mechanistic investigations revealed that MGO triggered substantial oxidative stress, evidenced by suppressed antioxidant enzyme activities (SOD and CAT decreased by approximately 30% and 28%, respectively, in the high-dose group) and elevated lipid peroxidation (MDA increased by 3.5-fold). Flow Cytometry:Article Title: Invasion of Clavibacter michiganensis into the Xylem and Surrounding Tissues Drives Histological Alterations and Disease Development in Tomato Article Snippet: The sections were gently rinsed with sterilized distilled water, placed on glass slides, and observed using a Article Title: CXM102 Regulates the Multiple Differentiation and Anti-Inflammation of Human Bone Marrow-Derived Leptin Receptor-Positive Stromal Cells In Vitro . Article Snippet: Bone marrow-derived leptin receptor-expressing (LepR) stromal cells (LepR BMSCs) have been identified as the primary source of osteoblasts, adipocytes, and fibroblasts in the bone marrow, and they play key roles in the maintenance of the bone marrow microenvironment; however, research on the fate and immunomodulatory changes of human LepR BMSCs is limited.. Here, we isolated LepR BMSCs from a young donor and studied their fate changes of osteogenic, adipogenic, myogenic differentiation, and immunomodulation with or without CXM102, a novel compound that we have previously demonstrated its anti-osteoporotic effects in mice.. Our results showed that CXM102 facilitated a preferential lineage shift toward osteogenesis from adipogenesis of LepR BMSCs in vitro, as evidenced by increased RUNX 2 expression and decreased PPARc in a bivalent differentiation system. Article Title: Microenvironment-informed carrier-free maltol-arginine nanoparticles harness CAT2-associated arginine transport for spermatogenic disorders. Article Snippet: Spermatogenic disorders are a major cause of male infertility, with oxidative stress-driven Leydig cell dysfunction serving as a key pathological contributor.. However, effective antioxidant therapy remains limited by insufficient accumulation in injured testes and by the formulation complexity associated with conventional carrier-based delivery systems.. Here, we investigated the pathological microenvironment of di(2-ethylhexyl) phthalate (DEHP)-injured testes and found increased inducible nitric oxide synthase (iNOS) expression together with upregulation of the cationic amino acid transporter 2 (CAT2) in the testicular interstitium, indicating altered arginine metabolism and transport. Article Title: Synergistic construction of low-temperature-resistant, water-retaining, and cushioning hydrogels via 1-s UV curing and ethylene glycol annealing for postharvest fruit protection. Article Snippet: Hydrogels are promising cushioning materials for fresh produce packaging because of their viscoelasticity, deformability, and energy-dissipation capability.. In this study, a UV-curable hydrogel based on methacrylated hyaluronic acid (HAMA) was developed.. Through ethylene glycol (EG) annealing, a cushioning material (HAMAEG) with good low-temperature tolerance and high water retention was fabricated. Article Title: Targeting the Calcium-mtDNA-cGAS-STING Signaling Nexus: A Novel Redox Mechanism for Nimodipine's Neuroprotection in Traumatic Brain Injury. Article Snippet: After incubation at 37 C for 1 h, cells were observed under a Article Title: zDHHC11 is a common palmitoyltransferase regulating microglia-mediated neuroinflammation across neurodegenerative diseases. Article Snippet: Purpose: Microglia-mediated neuroinflammation is a shared feature across Alzheimer's disease (AD), Parkinson's disease (PD), and diabetic cognitive impairment (DCI), but the convergent molecular mechanisms remain unclear.. This study investigated whether protein S-palmitoylation serves as a common regulator of microglial neuroinflammation across distinct neurodegenerative diseases etiologies and aimed to identify the key palmitoyltransferase involved.. Methods: In vivo ND models (APP/PS1 for AD, MPTP for PD, STZ/high-fat diet for DCI) and in vitro BV2 microglial models stimulated with amyloid-β (Aβ), lipopolysaccharide (LPS), or high glucose (HG) were established. Article Title: The PIEZO1/CISD1/IP3R Mechanotransduction Axis Drives Macrophage Mitochondrial Dysfunction and Inflammatory Activation in Pulmonary Fibrosis Article Snippet: Images were obtained under a Article Title: Methylglyoxal exposure at dietary-relevant concentrations induces cognitive deficits through dopaminergic damage system and metabolic perturbation in zebrafish larvae. Article Snippet: This study investigated the effects of MGO exposure at dietary-relevant concentrations on cognitive function and the underlying mechanisms using zebrafish larvae.. Behavioral assessments demonstrated that MGO induced dose-dependent cognitive impairment, with the medium and high dose groups showing a remarkable reduction in spatial memory and locomotor activity.. Mechanistic investigations revealed that MGO triggered substantial oxidative stress, evidenced by suppressed antioxidant enzyme activities (SOD and CAT decreased by approximately 30% and 28%, respectively, in the high-dose group) and elevated lipid peroxidation (MDA increased by 3.5-fold). Glass:Article Title: Invasion of Clavibacter michiganensis into the Xylem and Surrounding Tissues Drives Histological Alterations and Disease Development in Tomato Article Snippet: The sections were gently rinsed with sterilized distilled water, placed on glass slides, and observed using a Article Title: CXM102 Regulates the Multiple Differentiation and Anti-Inflammation of Human Bone Marrow-Derived Leptin Receptor-Positive Stromal Cells In Vitro . Article Snippet: Bone marrow-derived leptin receptor-expressing (LepR) stromal cells (LepR BMSCs) have been identified as the primary source of osteoblasts, adipocytes, and fibroblasts in the bone marrow, and they play key roles in the maintenance of the bone marrow microenvironment; however, research on the fate and immunomodulatory changes of human LepR BMSCs is limited.. Here, we isolated LepR BMSCs from a young donor and studied their fate changes of osteogenic, adipogenic, myogenic differentiation, and immunomodulation with or without CXM102, a novel compound that we have previously demonstrated its anti-osteoporotic effects in mice.. Our results showed that CXM102 facilitated a preferential lineage shift toward osteogenesis from adipogenesis of LepR BMSCs in vitro, as evidenced by increased RUNX 2 expression and decreased PPARc in a bivalent differentiation system. Article Title: Microenvironment-informed carrier-free maltol-arginine nanoparticles harness CAT2-associated arginine transport for spermatogenic disorders. Article Snippet: Spermatogenic disorders are a major cause of male infertility, with oxidative stress-driven Leydig cell dysfunction serving as a key pathological contributor.. However, effective antioxidant therapy remains limited by insufficient accumulation in injured testes and by the formulation complexity associated with conventional carrier-based delivery systems.. Here, we investigated the pathological microenvironment of di(2-ethylhexyl) phthalate (DEHP)-injured testes and found increased inducible nitric oxide synthase (iNOS) expression together with upregulation of the cationic amino acid transporter 2 (CAT2) in the testicular interstitium, indicating altered arginine metabolism and transport. Article Title: Synergistic construction of low-temperature-resistant, water-retaining, and cushioning hydrogels via 1-s UV curing and ethylene glycol annealing for postharvest fruit protection. Article Snippet: Hydrogels are promising cushioning materials for fresh produce packaging because of their viscoelasticity, deformability, and energy-dissipation capability.. In this study, a UV-curable hydrogel based on methacrylated hyaluronic acid (HAMA) was developed.. Through ethylene glycol (EG) annealing, a cushioning material (HAMAEG) with good low-temperature tolerance and high water retention was fabricated. Article Title: Targeting the Calcium-mtDNA-cGAS-STING Signaling Nexus: A Novel Redox Mechanism for Nimodipine's Neuroprotection in Traumatic Brain Injury. Article Snippet: After incubation at 37 C for 1 h, cells were observed under a Article Title: zDHHC11 is a common palmitoyltransferase regulating microglia-mediated neuroinflammation across neurodegenerative diseases. Article Snippet: Purpose: Microglia-mediated neuroinflammation is a shared feature across Alzheimer's disease (AD), Parkinson's disease (PD), and diabetic cognitive impairment (DCI), but the convergent molecular mechanisms remain unclear.. This study investigated whether protein S-palmitoylation serves as a common regulator of microglial neuroinflammation across distinct neurodegenerative diseases etiologies and aimed to identify the key palmitoyltransferase involved.. Methods: In vivo ND models (APP/PS1 for AD, MPTP for PD, STZ/high-fat diet for DCI) and in vitro BV2 microglial models stimulated with amyloid-β (Aβ), lipopolysaccharide (LPS), or high glucose (HG) were established. Article Title: The PIEZO1/CISD1/IP3R Mechanotransduction Axis Drives Macrophage Mitochondrial Dysfunction and Inflammatory Activation in Pulmonary Fibrosis Article Snippet: Images were obtained under a Article Title: Methylglyoxal exposure at dietary-relevant concentrations induces cognitive deficits through dopaminergic damage system and metabolic perturbation in zebrafish larvae. Article Snippet: This study investigated the effects of MGO exposure at dietary-relevant concentrations on cognitive function and the underlying mechanisms using zebrafish larvae.. Behavioral assessments demonstrated that MGO induced dose-dependent cognitive impairment, with the medium and high dose groups showing a remarkable reduction in spatial memory and locomotor activity.. Mechanistic investigations revealed that MGO triggered substantial oxidative stress, evidenced by suppressed antioxidant enzyme activities (SOD and CAT decreased by approximately 30% and 28%, respectively, in the high-dose group) and elevated lipid peroxidation (MDA increased by 3.5-fold). |